Fibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.

Silva, Pamuditha N; Altamentova, Svetlana M; Kilkenny, Dawn M; Rocheleau, Jonathan V

Silva, Pamuditha N; Altamentova, Svetlana M; Kilkenny, Dawn M; Rocheleau, Jonathan V.

Affiliation

Silva PN; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

J Biol Chem ; 288(24): 17859-70, 2013 Jun 14.

Article in En | MEDLINE | ID: mdl-23640895

Subject(s)

Insulin-Secreting Cells/enzymology; MAP Kinase Signaling System; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism; Receptor, Fibroblast Growth Factor, Type 5/metabolism; Secretory Vesicles/enzymology; Animals; Cell Adhesion; Cell Line; Endosomes/metabolism; Extracellular Matrix/metabolism; Humans; Insulin/metabolism; Insulin Secretion; Islets of Langerhans/cytology; Islets of Langerhans/metabolism; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Transport

Key words

Beta-cell; FGFR5; FGFRL1; Fibroblast Growth Factor Receptor (FGFR); MAP Kinases (MAPKs); PTPN6; Receptor Tyrosine Kinase; SHP-1; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MAP Kinase Signaling System / Secretory Vesicles / Insulin-Secreting Cells / Receptor, Fibroblast Growth Factor, Type 5 / Protein Tyrosine Phosphatase, Non-Receptor Type 6 Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: Canada

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