A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

Richter, Suzanne; Bedard, Philippe L; Chen, Eric Xueyu; Clarke, Blaise A; Tran, Ben; Hotte, Sebastien J; Stathis, Anastasios; Hirte, Hal W; Razak, Albiruni R A; Reedijk, Michael; Chen, Zhuo; Cohen, Brenda; Zhang, Wen-Jiang; Wang, Lisa; Ivy, S Percy; Moore, Malcolm J; Oza, Amit M; Siu, Lillian L; McWhirter, Elaine

Richter, Suzanne; Bedard, Philippe L; Chen, Eric Xueyu; Clarke, Blaise A; Tran, Ben; Hotte, Sebastien J; Stathis, Anastasios; Hirte, Hal W; Razak, Albiruni R A; Reedijk, Michael; Chen, Zhuo; Cohen, Brenda; Zhang, Wen-Jiang; Wang, Lisa; Ivy, S Percy; Moore, Malcolm J; Oza, Amit M; Siu, Lillian L; McWhirter, Elaine.

Affiliation

Richter S; Princess Margaret Cancer Centre, Drug Development Program, 610 University Avenue, Toronto, Canada, M5G 2M9.

Invest New Drugs ; 32(2): 243-9, 2014 Apr.

Article in En | MEDLINE | ID: mdl-23645447

Subject(s)

Amyloid Precursor Protein Secretases/antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Neoplasms/drug therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Benzazepines/administration & dosage; Benzazepines/adverse effects; Benzazepines/pharmacokinetics; Calcium-Binding Proteins/metabolism; Deoxycytidine/administration & dosage; Deoxycytidine/adverse effects; Deoxycytidine/analogs & derivatives; Deoxycytidine/pharmacokinetics; Female; Humans; Intercellular Signaling Peptides and Proteins/metabolism; Male; Membrane Proteins/metabolism; Middle Aged; Neoplasms/metabolism; Receptor, Notch1/metabolism; Receptor, Notch3; Receptors, Notch/metabolism; Serrate-Jagged Proteins; Gemcitabine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Amyloid Precursor Protein Secretases / Neoplasms Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2014 Type: Article

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