VEGF induces TGF-ß1 expression and myofibroblast transformation after glaucoma surgery.

Park, Hae-Young L; Kim, Jie Hyun; Park, Chan Kee

Park, Hae-Young L; Kim, Jie Hyun; Park, Chan Kee.

Affiliation

Park HY; Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Am J Pathol ; 182(6): 2147-54, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23684430

Subject(s)

Myofibroblasts/drug effects; Trabeculectomy/adverse effects; Transforming Growth Factor beta1/biosynthesis; Vascular Endothelial Growth Factor A/pharmacology; Animals; Antibodies, Monoclonal, Humanized/pharmacology; Bevacizumab; Conjunctiva/metabolism; Conjunctiva/ultrastructure; Dose-Response Relationship, Drug; Epithelial Cells/ultrastructure; Fibrosis; Male; Microscopy, Electron; Myofibroblasts/metabolism; Postoperative Period; Rabbits; Signal Transduction/drug effects; Signal Transduction/physiology; Smad Proteins/biosynthesis; Snail Family Transcription Factors; Transcription Factors/biosynthesis; Up-Regulation/physiology; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor A/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trabeculectomy / Vascular Endothelial Growth Factor A / Transforming Growth Factor beta1 / Myofibroblasts Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2013 Type: Article

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