In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors.

Xia, Chun-Fang; Chen, Gang; Gangadharmath, Umesh; Gomez, Luis F; Liang, Qianwa; Mu, Fanrong; Mocharla, Vani P; Su, Helen; Szardenings, A Katrin; Walsh, Joseph C; Zhao, Tieming; Kolb, Hartmuth C

Xia, Chun-Fang; Chen, Gang; Gangadharmath, Umesh; Gomez, Luis F; Liang, Qianwa; Mu, Fanrong; Mocharla, Vani P; Su, Helen; Szardenings, A Katrin; Walsh, Joseph C; Zhao, Tieming; Kolb, Hartmuth C.

Affiliation

Xia CF; Molecular Imaging Biomarker Research, Siemens Medical Solutions USA, Inc., 6100 Bristol Parkway, Culver City, CA, 90230, USA.

Mol Imaging Biol ; 15(6): 748-57, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23689985

Subject(s)

Apoptosis; Glycopeptides/pharmacokinetics; Molecular Imaging/methods; Neoplasms/diagnostic imaging; Positron-Emission Tomography/methods; Radiopharmaceuticals/pharmacokinetics; Animals; Caspase 3/analysis; Caspase 3/metabolism; Caspase 7/analysis; Caspase 7/metabolism; Cell Line, Tumor; Glycopeptides/chemistry; Humans; Linear Models; Mice; Radiopharmaceuticals/chemistry; Tissue Distribution; Xenograft Model Antitumor Assays

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycopeptides / Apoptosis / Radiopharmaceuticals / Positron-Emission Tomography / Molecular Imaging / Neoplasms Limits: Animals / Humans Language: En Journal: Mol Imaging Biol Journal subject: BIOLOGIA MOLECULAR / DIAGNOSTICO POR IMAGEM Year: 2013 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google