Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects.

Miller, Ann K; Harrell, Emma; Ye, Li; Baptiste-Brown, Sharon; Kleim, Jorg-Peter; Ohrt, Colin; Duparc, Stephan; Möhrle, Jörg J; Webster, Alison; Stinnett, Sandra; Hughes, Arlene; Griffith, Sandy; Beelen, Andrew P

Miller, Ann K; Harrell, Emma; Ye, Li; Baptiste-Brown, Sharon; Kleim, Jorg-Peter; Ohrt, Colin; Duparc, Stephan; Möhrle, Jörg J; Webster, Alison; Stinnett, Sandra; Hughes, Arlene; Griffith, Sandy; Beelen, Andrew P.

Affiliation

Miller AK; GSK, King of Prussia, PA, USA.

Br J Clin Pharmacol ; 76(6): 858-67, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23701202

Subject(s)

Aminoquinolines; Antimalarials; Chloroquine; Administration, Oral; Adolescent; Adult; Aminoquinolines/administration & dosage; Aminoquinolines/adverse effects; Aminoquinolines/pharmacokinetics; Antimalarials/administration & dosage; Antimalarials/adverse effects; Antimalarials/pharmacokinetics; Area Under Curve; Chloroquine/administration & dosage; Chloroquine/adverse effects; Chloroquine/pharmacokinetics; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase/genetics; Glucosephosphate Dehydrogenase/metabolism; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Young Adult

Key words

chloroquine; malaria; pharmacokinetics; radical cure; tafenoquine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chloroquine / Aminoquinolines / Antimalarials Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2013 Type: Article Affiliation country: United States

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