Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat thyroid cells.

Chiappini, Florencia; Pontillo, Carolina; Randi, Andrea S; Alvarez, Laura; Kleiman de Pisarev, Diana L

Chiappini, Florencia; Pontillo, Carolina; Randi, Andrea S; Alvarez, Laura; Kleiman de Pisarev, Diana L.

Affiliation

Chiappini F; Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina.

Toxicol Sci ; 134(2): 276-90, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23708402

Subject(s)

Apoptosis/drug effects; Extracellular Signal-Regulated MAP Kinases/metabolism; Hexachlorobenzene/toxicity; Reactive Oxygen Species/metabolism; Thyroid Gland/drug effects; Animals; Caspases/metabolism; Cell Line; Enzyme Activation; Mitochondria/drug effects; Phosphorylation; Rats; Thyroid Gland/cytology; Thyroid Gland/metabolism

Key words

ERK1/2.; FRTL-5 cells; apoptosis; hexachlorobenzene; reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Gland / Reactive Oxygen Species / Apoptosis / Extracellular Signal-Regulated MAP Kinases / Hexachlorobenzene Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2013 Type: Article Affiliation country: Argentina

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