Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells.

Chen, Hui-Jye; Lin, Chung-Ming; Lee, Chao-Ying; Shih, Nai-Chen; Peng, Shu-Fen; Tsuzuki, Minoru; Amagaya, Sakae; Huang, Wen-Wen; Yang, Jai-Sing

Chen, Hui-Jye; Lin, Chung-Ming; Lee, Chao-Ying; Shih, Nai-Chen; Peng, Shu-Fen; Tsuzuki, Minoru; Amagaya, Sakae; Huang, Wen-Wen; Yang, Jai-Sing.

Affiliation

Chen HJ; Graduate Institute of Molecular Systems Biomedicine, Department of Pharmacology, China Medical University, Taichung 40402, Taiwan, ROC.

Oncol Rep ; 30(2): 925-32, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23708932

Subject(s)

Bone Neoplasms/drug therapy; Kaempferols/pharmacology; MAP Kinase Signaling System/drug effects; Osteosarcoma/drug therapy; Signal Transduction/drug effects; Transcription Factor AP-1/metabolism; Bone Neoplasms/genetics; Bone Neoplasms/metabolism; Bone Neoplasms/pathology; Cell Adhesion/drug effects; Cell Adhesion/genetics; Cell Line, Tumor; Cell Movement/drug effects; Cell Movement/genetics; Down-Regulation/drug effects; Down-Regulation/genetics; Humans; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Neoplasm Metastasis; Osteosarcoma/genetics; Osteosarcoma/metabolism; Osteosarcoma/pathology; Phosphorylation; RNA, Messenger/genetics; RNA, Messenger/metabolism; Urokinase-Type Plasminogen Activator/genetics; Urokinase-Type Plasminogen Activator/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Signal Transduction / Osteosarcoma / Transcription Factor AP-1 / MAP Kinase Signaling System / Kaempferols Limits: Humans Language: En Journal: Oncol Rep Journal subject: NEOPLASIAS Year: 2013 Type: Article

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