Subcutaneously administered ofatumumab in rheumatoid arthritis: a phase I/II study of safety, tolerability, pharmacokinetics, and pharmacodynamics.

Kurrasch, Regina; Brown, Judith C; Chu, Myron; Craigen, Jenny; Overend, Philip; Patel, Bela; Wolfe, Steven; Chang, David J

Kurrasch, Regina; Brown, Judith C; Chu, Myron; Craigen, Jenny; Overend, Philip; Patel, Bela; Wolfe, Steven; Chang, David J.

Affiliation

Kurrasch R; GlaxoSmithKline (GSK), King of Prussia, Pennsylvania, USA. regina.h.kurrasch@gsk.com

J Rheumatol ; 40(7): 1089-96, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23729801

Subject(s)

Antibodies, Monoclonal/therapeutic use; Antirheumatic Agents/therapeutic use; Arthritis, Rheumatoid/drug therapy; Methotrexate/therapeutic use; Adult; Aged; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal, Humanized; Antirheumatic Agents/administration & dosage; Antirheumatic Agents/adverse effects; Antirheumatic Agents/pharmacokinetics; Drug Therapy, Combination; Female; Humans; Hypodermoclysis; Male; Methotrexate/administration & dosage; Methotrexate/adverse effects; Middle Aged; Single-Blind Method; Treatment Outcome

Key words

B LYMPHOCYTES; BIOLOGICAL THERAPY; CLINICAL TRIALS; PHARMACOKINETICS; RHEUMATOID ARTHRITIS

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Methotrexate / Antirheumatic Agents / Antibodies, Monoclonal Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Rheumatol Year: 2013 Type: Article Affiliation country: United States

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