Flt-1 (vascular endothelial growth factor receptor-1) is essential for the vascular endothelial growth factor-Notch feedback loop during angiogenesis.

Chappell, John C; Mouillesseaux, Kevin P; Bautch, Victoria L

Chappell, John C; Mouillesseaux, Kevin P; Bautch, Victoria L.

Affiliation

Chappell JC; Department of Biology, The University of North Carolina at Chapel Hill, NC 27599, USA.

Arterioscler Thromb Vasc Biol ; 33(8): 1952-9, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23744993

Subject(s)

Neovascularization, Physiologic/physiology; Receptors, Notch/metabolism; Signal Transduction/physiology; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor Receptor-1/metabolism; Zebrafish Proteins/metabolism; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Animals; Cell Proliferation; Dipeptides/pharmacology; Embryonic Stem Cells/metabolism; Endothelium, Vascular/abnormalities; Endothelium, Vascular/embryology; Endothelium, Vascular/metabolism; Feedback, Physiological/drug effects; Feedback, Physiological/physiology; Gene Expression Regulation, Developmental/physiology; Mice; Mice, Knockout; Receptors, Notch/antagonists & inhibitors; Signal Transduction/drug effects; Vascular Endothelial Growth Factor Receptor-1/genetics; Veins/abnormalities; Veins/embryology; Veins/metabolism; Zebrafish; Zebrafish Proteins/genetics

Key words

Flt-1 protein, mouse; Notch receptors; angiogenesis; embryonic stem cells; vascular endothelial growth factor A; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Neovascularization, Physiologic / Zebrafish Proteins / Vascular Endothelial Growth Factor Receptor-1 / Vascular Endothelial Growth Factor A / Receptors, Notch Limits: Animals Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2013 Type: Article Affiliation country: United States

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