A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn²âº.

Kato, Jungo; Hayashi, Mariko Kato; Aizu, Shinnosuke; Yukutake, Yoshinori; Takeda, Junzo; Yasui, Masato

A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn²âº.

Kato, Jungo; Hayashi, Mariko Kato; Aizu, Shinnosuke; Yukutake, Yoshinori; Takeda, Junzo; Yasui, Masato.

Affiliation

Kato J; Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.

Biochem J ; 454(2): 275-82, 2013 Sep 01.

Article in En | MEDLINE | ID: mdl-23772702

Subject(s)

Anesthetics, Intravenous/pharmacology; Aquaporin 4/antagonists & inhibitors; Lipid Bilayers/metabolism; Propofol/pharmacology; Zinc/metabolism; Amino Acid Substitution; Aquaporin 1/antagonists & inhibitors; Aquaporin 1/chemistry; Aquaporin 1/genetics; Aquaporin 1/metabolism; Aquaporin 4/chemistry; Aquaporin 4/genetics; Aquaporin 4/metabolism; Cysteine/chemistry; Humans; Liposomes; Molecular Weight; Mutagenesis, Site-Directed; Mutant Proteins/antagonists & inhibitors; Mutant Proteins/chemistry; Mutant Proteins/metabolism; Native Polyacrylamide Gel Electrophoresis; Osmolar Concentration; Permeability/drug effects; Protein Isoforms/antagonists & inhibitors; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Structure, Tertiary; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Water/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zinc / Propofol / Anesthetics, Intravenous / Aquaporin 4 / Lipid Bilayers Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem J Year: 2013 Type: Article Affiliation country: Japan

Fulltext

XML

PubMed Links

Search on Google