Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2.

Sprowl, Jason A; Ciarimboli, Giuliano; Lancaster, Cynthia S; Giovinazzo, Hugh; Gibson, Alice A; Du, Guoqing; Janke, Laura J; Cavaletti, Guido; Shields, Anthony F; Sparreboom, Alex

Sprowl, Jason A; Ciarimboli, Giuliano; Lancaster, Cynthia S; Giovinazzo, Hugh; Gibson, Alice A; Du, Guoqing; Janke, Laura J; Cavaletti, Guido; Shields, Anthony F; Sparreboom, Alex.

Affiliation

Sprowl JA; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Proc Natl Acad Sci U S A ; 110(27): 11199-204, 2013 Jul 02.

Article in En | MEDLINE | ID: mdl-23776246

Subject(s)

Neurotoxicity Syndromes/etiology; Neurotoxicity Syndromes/metabolism; Organic Cation Transport Proteins/physiology; Organoplatinum Compounds/toxicity; Animals; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/toxicity; Female; Ganglia, Spinal/drug effects; Ganglia, Spinal/metabolism; Humans; Male; Mice; Mice, Knockout; Neurotoxicity Syndromes/genetics; Octamer Transcription Factor-1/deficiency; Octamer Transcription Factor-1/genetics; Octamer Transcription Factor-1/physiology; Organic Cation Transport Proteins/deficiency; Organic Cation Transport Proteins/genetics; Organic Cation Transporter 2; Organoplatinum Compounds/pharmacokinetics; Oxaliplatin

Key words

chemotherapy; neuropathy; solute carriers

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Neurotoxicity Syndromes / Organic Cation Transport Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Type: Article Affiliation country: United States

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