The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.

Pybus, Brandon S; Marcsisin, Sean R; Jin, Xiannu; Deye, Gregory; Sousa, Jason C; Li, Qigui; Caridha, Diana; Zeng, Qiang; Reichard, Gregory A; Ockenhouse, Christian; Bennett, Jason; Walker, Larry A; Ohrt, Colin; Melendez, Victor

Pybus, Brandon S; Marcsisin, Sean R; Jin, Xiannu; Deye, Gregory; Sousa, Jason C; Li, Qigui; Caridha, Diana; Zeng, Qiang; Reichard, Gregory A; Ockenhouse, Christian; Bennett, Jason; Walker, Larry A; Ohrt, Colin; Melendez, Victor.

Malar J ; 12: 212, 2013 Jun 20.

Article in En | MEDLINE | ID: mdl-23782898

Subject(s)

Antimalarials/metabolism; Cytochrome P-450 CYP2D6/genetics; Cytochrome P-450 CYP2D6/metabolism; Primaquine/metabolism; Animals; Antimalarials/chemistry; Antimalarials/pharmacokinetics; Antimalarials/therapeutic use; Hydroxylation; Malaria/drug therapy; Malaria/parasitology; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Plasmodium berghei; Primaquine/chemistry; Primaquine/pharmacokinetics; Primaquine/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Primaquine / Cytochrome P-450 CYP2D6 / Antimalarials Limits: Animals Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2013 Type: Article

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