Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations.

Zhao, Jian-Yuan; Qiao, Bin; Duan, Wen-Yuan; Gong, Xiao-Hong; Peng, Qian-Qian; Jiang, Song-Shan; Lu, Chen-Qi; Chen, Yi-Jiang; Shen, Hong-Bing; Huang, Guo-Ying; Jin, Li; Wang, Hong-Yan

Zhao, Jian-Yuan; Qiao, Bin; Duan, Wen-Yuan; Gong, Xiao-Hong; Peng, Qian-Qian; Jiang, Song-Shan; Lu, Chen-Qi; Chen, Yi-Jiang; Shen, Hong-Bing; Huang, Guo-Ying; Jin, Li; Wang, Hong-Yan.

Affiliation

Zhao JY; The State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.

Eur Heart J ; 35(11): 733-42, 2014 Mar.

Article in En | MEDLINE | ID: mdl-23798577

Subject(s)

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics; Heart Defects, Congenital/genetics; Asian People/genetics; Case-Control Studies; DNA Methylation/genetics; Ferredoxin-NADP Reductase/genetics; Gene Expression/genetics; Genetic Predisposition to Disease/genetics; Genotype; Homocysteine/metabolism; Humans; Hyperhomocysteinemia/genetics; MicroRNAs/genetics; Risk Factors; Transcription, Genetic/genetics

Key words

Congenital heart disease; Genetic variant; Homocysteine; Methionine synthase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Heart Defects, Congenital Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur Heart J Year: 2014 Type: Article Affiliation country: China

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