Crystal structure of the N-terminal domain of EccA1 ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.
Proteins
; 82(1): 159-63, 2014 Jan.
Article
in En
| MEDLINE
| ID: mdl-23818233
ABSTRACT
EccA1 is an important component of the type VII secretion system (T7SS) that is responsible for transport of virulence factors in pathogenic mycobacteria. EccA1 has an N-terminal domain of unknown function and a C-terminal AAA+ (ATPases associated with various cellular activities) domain. Here we report the crystal structure of the N-terminal domain of EccA1 from Mycobacterium tuberculosis, which shows an arrangement of six tetratricopeptide repeats that may mediate interactions of EccA1 with secreted substrates. Furthermore, the size and shape of the N-terminal domain suggest its orientation in the context of a hexamer model of full-length EccA1.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Molecular
/
Adenosine Triphosphatases
/
Bacterial Secretion Systems
/
Mycobacterium tuberculosis
Type of study:
Prognostic_studies
Language:
En
Journal:
Proteins
Journal subject:
BIOQUIMICA
Year:
2014
Type:
Article