Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output.

Jensen, Kristin; Rother, Magdalena B; Brusletto, Berit Sletbakk; Olstad, Ole K; Dalsbotten Aass, Hans Christian; van Zelm, Menno C; Kierulf, Peter; Gautvik, Kaare M

Jensen, Kristin; Rother, Magdalena B; Brusletto, Berit Sletbakk; Olstad, Ole K; Dalsbotten Aass, Hans Christian; van Zelm, Menno C; Kierulf, Peter; Gautvik, Kaare M.

Affiliation

Jensen K; Department of Medical Biochemistry, Oslo University Hospital, 0407 Oslo, Norway. kristin.jensen@medisin.uio.no

J Immunol ; 191(3): 1210-9, 2013 Aug 01.

Article in En | MEDLINE | ID: mdl-23825313

Subject(s)

B-Lymphocyte Subsets/immunology; Basic Helix-Loop-Helix Transcription Factors/metabolism; Inhibitor of Differentiation Protein 2/metabolism; Precursor Cells, B-Lymphoid/immunology; Precursor Cells, B-Lymphoid/metabolism; Antigens, Nuclear/metabolism; Bone Marrow/metabolism; Cell Differentiation; Cell Proliferation; DNA Nucleotidylexotransferase/metabolism; DNA-Activated Protein Kinase/metabolism; DNA-Binding Proteins/metabolism; Gene Expression Profiling; Homeodomain Proteins/metabolism; Humans; Infant; Inhibitor of Differentiation Protein 2/biosynthesis; Inhibitor of Differentiation Protein 2/genetics; Ki-67 Antigen/biosynthesis; Ku Autoantigen; Lymphocyte Count; Middle Aged; Nuclear Proteins/metabolism; RNA, Messenger/biosynthesis; Signal Transduction/immunology; Up-Regulation; V(D)J Recombination/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocyte Subsets / Basic Helix-Loop-Helix Transcription Factors / Inhibitor of Differentiation Protein 2 / Precursor Cells, B-Lymphoid Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Infant / Middle aged Language: En Journal: J Immunol Year: 2013 Type: Article Affiliation country: Norway

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