Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells.

Tardif, Virginie; Riquelme, Sebastián A; Remy, Séverine; Carreño, Leandro J; Cortés, Claudia M; Simon, Thomas; Hill, Marcelo; Louvet, Cédric; Riedel, Claudia A; Blancou, Philippe; Bach, Jean-Marie; Chauveau, Christine; Bueno, Susan M; Anegon, Ignacio; Kalergis, Alexis M

Tardif, Virginie; Riquelme, Sebastián A; Remy, Séverine; Carreño, Leandro J; Cortés, Claudia M; Simon, Thomas; Hill, Marcelo; Louvet, Cédric; Riedel, Claudia A; Blancou, Philippe; Bach, Jean-Marie; Chauveau, Christine; Bueno, Susan M; Anegon, Ignacio; Kalergis, Alexis M.

Affiliation

Tardif V; INSERM, UMR 1064, Nantes, France; CHU Nantes, ITUN, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France.

Eur J Immunol ; 43(11): 2832-44, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23852701

Subject(s)

Antigen Presentation/immunology; Carbon Monoxide/metabolism; Endosomes/metabolism; Lysosomes/metabolism; Animals; Antigen Presentation/drug effects; CD4-Positive T-Lymphocytes/immunology; Carbon Monoxide/pharmacology; Cells, Cultured; Dendritic Cells/drug effects; Dendritic Cells/immunology; Dendritic Cells/metabolism; Endocytosis/immunology; Endosomes/drug effects; Heme Oxygenase-1/immunology; Heme Oxygenase-1/metabolism; Histocompatibility Antigens Class I/immunology; Histocompatibility Antigens Class II/immunology; Lipopolysaccharides/immunology; Lymphocyte Activation/immunology; Lysosomes/drug effects; Membrane Proteins/immunology; Membrane Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin/immunology

Key words

Antigen processing; Carbon monoxide; Cross-presentation; Endocytosis; Heme oxygenase-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Carbon Monoxide / Antigen Presentation / Lysosomes Limits: Animals Language: En Journal: Eur J Immunol Year: 2013 Type: Article Affiliation country: France

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