Bioactive insulin microparticles produced by supercritical fluid assisted atomization with an enhanced mixer.

Du, Zhe; Tang, Chuan; Guan, Yi-Xin; Yao, Shan-Jing; Zhu, Zi-Qiang

Du, Zhe; Tang, Chuan; Guan, Yi-Xin; Yao, Shan-Jing; Zhu, Zi-Qiang.

Affiliation

Du Z; Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Int J Pharm ; 454(1): 174-82, 2013 Sep 15.

Article in En | MEDLINE | ID: mdl-23860361

Subject(s)

Excipients/chemistry; Hypoglycemic Agents/chemistry; Insulin/chemistry; Technology, Pharmaceutical/methods; Administration, Inhalation; Animals; Blood Glucose/drug effects; Blood Glucose/metabolism; Chemical Precipitation; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Circular Dichroism; Drug Stability; Excipients/administration & dosage; Hydrogen-Ion Concentration; Hypoglycemic Agents/administration & dosage; Injections, Intravenous; Insulin/administration & dosage; Male; Nebulizers and Vaporizers; Particle Size; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry

Key words

Bioactivity; Hydrodynamic cavitation mixer; Insulin; Micronization; Supercritical fluid assisted atomization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Technology, Pharmaceutical / Excipients / Hypoglycemic Agents / Insulin Limits: Animals Language: En Journal: Int J Pharm Year: 2013 Type: Article Affiliation country: China

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