Hypothermia for pediatric refractory status epilepticus.
Epilepsia
; 54(9): 1586-94, 2013 Sep.
Article
in En
| MEDLINE
| ID: mdl-23906244
ABSTRACT
PURPOSE:
Refractory status epilepticus (RSE) is a life-threatening emergency, demonstrating, by definition, significant pharmacoresistance. We describe five cases of pediatric RSE treated with mild hypothermia.METHODS:
Retrospective chart review was performed of records of children who received hypothermia for RSE at two tertiary-care pediatric hospitals between 2009 and 2012. KEYFINDINGS:
Five children with RSE received mild hypothermia (32-35°C). Hypothermia reduced seizure burden during and after treatment in all cases. Prior to initiation of hypothermia, four children (80%) received pentobarbital infusions to treat RSE, but relapsed after pentobarbital discontinuation. No child relapsed after treatment with hypothermia. One child died after redirection of care. Remaining four children were discharged.SIGNIFICANCE:
This is the largest pediatric case series reporting treatment of RSE with mild hypothermia. Hypothermia decreased seizure burden during and after pediatric RSE and may prevent RSE relapse.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seizures
/
Status Epilepticus
/
Hypothermia, Induced
Type of study:
Observational_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Epilepsia
Year:
2013
Type:
Article
Affiliation country:
United States