Helminth-excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway.

Terrazas, César A; Alcántara-Hernández, Marcela; Bonifaz, Laura; Terrazas, Luis I; Satoskar, Abhay R

Terrazas, César A; Alcántara-Hernández, Marcela; Bonifaz, Laura; Terrazas, Luis I; Satoskar, Abhay R.

Affiliation

Terrazas CA; 1A.S., Department of Pathology, The Ohio State University, Columbus, OH 43210, USA. abhay.satoskar@osumc.edu.

FASEB J ; 27(11): 4547-60, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23907435

Subject(s)

Dendritic Cells/immunology; Proto-Oncogene Proteins c-raf/metabolism; Taenia/immunology; Th2 Cells/immunology; Toll-Like Receptor 2/metabolism; Animals; Asialoglycoproteins/genetics; Asialoglycoproteins/metabolism; Dendritic Cells/metabolism; Down-Regulation; Immunomodulation; Interleukin-12/metabolism; Lectins, C-Type/genetics; Lectins, C-Type/metabolism; MAP Kinase Signaling System; Mannose Receptor; Mannose-Binding Lectins/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Receptors, Cell Surface/metabolism; Th2 Cells/metabolism; Transcription Factor RelA/metabolism; Tumor Necrosis Factor-alpha/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

CLRs; MGL; dendritic cell; immunomodulation; mannose receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taenia / Dendritic Cells / Th2 Cells / Proto-Oncogene Proteins c-raf / Toll-Like Receptor 2 Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2013 Type: Article Affiliation country: United States

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