Septo-hippocampal GABAergic signaling across multiple modalities in awake mice.
Nat Neurosci
; 16(9): 1182-4, 2013 Sep.
Article
in En
| MEDLINE
| ID: mdl-23912949
ABSTRACT
Hippocampal interneurons receive GABAergic input from the medial septum. Using two-photon Ca(2+) imaging of axonal boutons in hippocampal CA1 of behaving mice, we found that populations of septo-hippocampal GABAergic boutons were activated during locomotion and salient sensory events; sensory responses scaled with stimulus intensity and were abolished by anesthesia. We found similar activity patterns among boutons with common putative postsynaptic targets, with low-dimensional bouton population dynamics being driven primarily by presynaptic spiking.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wakefulness
/
Signal Transduction
/
Septum of Brain
/
Gamma-Aminobutyric Acid
/
Hippocampus
/
Neural Pathways
Limits:
Animals
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2013
Type:
Article
Affiliation country:
United States