Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase.

Chen, Shih-Hsun; Lin, Sheng-Wei; Lin, Shen-Rong; Liang, Po-Huang; Yang, Jinn-Moon

Chen, Shih-Hsun; Lin, Sheng-Wei; Lin, Shen-Rong; Liang, Po-Huang; Yang, Jinn-Moon.

Affiliation

Chen SH; Department of Biological Science and Technology, National Chiao Tung University , Hsinchu 30050, Taiwan.

J Chem Inf Model ; 53(9): 2299-311, 2013 Sep 23.

Article in En | MEDLINE | ID: mdl-23919676

Subject(s)

Drug Evaluation, Preclinical/methods; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Farnesyltranstransferase/antagonists & inhibitors; Binding Sites; Cell Line, Tumor; Cell Proliferation/drug effects; Enzyme Inhibitors/metabolism; Farnesyltranstransferase/chemistry; Farnesyltranstransferase/genetics; Farnesyltranstransferase/metabolism; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Evaluation, Preclinical / Enzyme Inhibitors / Farnesyltranstransferase Limits: Humans Language: En Journal: J Chem Inf Model Journal subject: INFORMATICA MEDICA / QUIMICA Year: 2013 Type: Article Affiliation country: Taiwan

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