Marine n-3 fatty acids in adipose tissue and development of atrial fibrillation: a Danish cohort study.
Heart
; 99(20): 1519-24, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23945170
ABSTRACT
OBJECTIVE:
Consumption of fish and marine n-3 polyunsaturated fatty acids (PUFA) may be associated with a lower risk of atrial fibrillation (AF), but results have been inconsistent. The aim was to investigate this further by measurements of marine n-3 PUFA in adipose tissue.DESIGN:
Cohort study.SETTING:
A total of 57 053 Danish participants 50-64 years of age were enrolled into the Diet, Cancer and Health Cohort Study. PATIENTS A randomly drawn subcohort of 3440 participants with available data from baseline adipose tissue biopsies.INTERVENTIONS:
Exposure was the adipose tissue content of marine n-3 PUFA, which reflects the endogenous exposure and is also an objective marker of the long-term dietary intake. MAIN OUTCOMEMEASURES:
Incident AF during follow-up.RESULTS:
179 cases of AF occurred over 13.6 years. Multivariate, sex-stratified Cox proportional hazards regression analyses using cubic splines showed a monotonic, negative, dose-response trend, but not statistically significant association, between total marine n-3 PUFA in adipose tissue and incident AF. A similar trend towards a lower risk of AF was seen in the second (HR 0.87, 95% CI 0.60 to 1.24) and third tertiles (HR 0.77, 95% CI 0.53 to 1.10) of marine n-3 PUFA compared with the lowest tertile. Similar trends, but also not statistically significant, were found separately for eicosapentaenoic, docosahexaenoic and docosapentaenoic acids.CONCLUSIONS:
There was no statistically significant association between the content of marine n-3 PUFA in adipose tissue and the development of AF; however, data showed a monotonic, negative dose-response trend suggestive of a negative association.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Atrial Fibrillation
/
Dietary Fats, Unsaturated
/
Fatty Acids, Omega-3
/
Adipose Tissue
/
Population Surveillance
/
Seafood
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Heart
Journal subject:
CARDIOLOGIA
Year:
2013
Type:
Article
Affiliation country:
Denmark