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Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with Lewis Y on endothelial cells.
Lin, Wei-Ling; Chang, Chuan-Fa; Shi, Chung-Sheng; Shi, Guey-Yueh; Wu, Hua-Lin.
Affiliation
  • Lin WL; From the Department of Biochemistry and Molecular Biology (W.-L.L., C.-S.S., G.-Y.S., H.-L.W.); Institute of Basic Medical Sciences (W.-L.L.); Cardiovascular Research Center (W.-L.L., G.-Y.S., H.-L.W.); Center of Bioscience and Biotechnology (H.-L.W.); and Department of Medical Laboratory Science and Biotechnology (C.-F.C.), College of Medicine, National Cheng Kung University, Tainan City, Taiwan.
Arterioscler Thromb Vasc Biol ; 33(10): 2366-73, 2013 Oct.
Article in En | MEDLINE | ID: mdl-23950139
Subject(s)
Anti-Inflammatory Agents/administration & dosage; Atherosclerosis/prevention & control; Chemotaxis, Leukocyte/drug effects; Endothelial Cells/drug effects; Leukocytes, Mononuclear/drug effects; Lewis Blood Group Antigens/metabolism; Neutrophils/drug effects; Thrombomodulin/administration & dosage; Vasculitis/prevention & control; Animals; Anti-Inflammatory Agents/metabolism; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/immunology; Atherosclerosis/metabolism; Atherosclerosis/pathology; Carotid Artery Injuries/immunology; Carotid Artery Injuries/metabolism; Carotid Artery Injuries/pathology; Cell Adhesion/drug effects; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells/immunology; Endothelial Cells/metabolism; Endothelial Cells/pathology; HEK293 Cells; Human Umbilical Vein Endothelial Cells/immunology; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Leukocytes, Mononuclear/immunology; Leukocytes, Mononuclear/metabolism; Lewis Blood Group Antigens/immunology; Macrophages/drug effects; Macrophages/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils/immunology; Neutrophils/metabolism; Plaque, Atherosclerotic; Protein Structure, Tertiary; Recombinant Proteins/administration & dosage; Thrombomodulin/metabolism; Transendothelial and Transepithelial Migration/drug effects; Tumor Necrosis Factor-alpha/metabolism; Vasculitis/immunology; Vasculitis/metabolism; Vasculitis/pathology
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / Leukocytes, Mononuclear / Chemotaxis, Leukocyte / Thrombomodulin / Endothelial Cells / Atherosclerosis / Lewis Blood Group Antigens / Anti-Inflammatory Agents / Neutrophils Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2013 Type: Article Affiliation country: Taiwan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / Leukocytes, Mononuclear / Chemotaxis, Leukocyte / Thrombomodulin / Endothelial Cells / Atherosclerosis / Lewis Blood Group Antigens / Anti-Inflammatory Agents / Neutrophils Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2013 Type: Article Affiliation country: Taiwan