Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.

Ye, Cai Guo; Chen, George G; Ho, Rocky L K; Merchant, Juanita L; He, Ming-Liang; Lai, Paul B S

Ye, Cai Guo; Chen, George G; Ho, Rocky L K; Merchant, Juanita L; He, Ming-Liang; Lai, Paul B S.

Affiliation

Ye CG; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; China-America Cancer Research Institute, Guangdong Medical College, Dongguan 523808, PR China.
Chen GG; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. Electronic address: gchen@cuhk.edu.hk.
Ho RLK; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Merchant JL; Internal Medicine-Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
He ML; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Lai PBS; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Biochim Biophys Acta ; 1833(12): 2970-2979, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23954442

Subject(s)

DNA-Binding Proteins/metabolism; Epigenesis, Genetic; Transcription Factors/metabolism; Up-Regulation/genetics; bcl-2 Homologous Antagonist-Killer Protein/genetics; Acetylation/drug effects; Animals; Apoptosis/drug effects; Apoptosis/genetics; Base Sequence; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; CpG Islands/genetics; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methylation/drug effects; DNA Methylation/genetics; Down-Regulation/drug effects; Down-Regulation/genetics; Epigenesis, Genetic/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Humans; Liver Neoplasms/genetics; Liver Neoplasms/pathology; Mice; Mice, Nude; Molecular Sequence Data; Promoter Regions, Genetic/genetics; Protein Binding/drug effects; Up-Regulation/drug effects; Xenograft Model Antitumor Assays; bcl-2 Homologous Antagonist-Killer Protein/metabolism

Key words

5-Aza-dC; 5-aza-2'-deoxycytidine; Bak; ChIP; Co-IP; DNA methyltransferase; DNMT; HCC; HDAC; Hepatocellular carcinoma; MIHA; MeCP2; VPA; ZBP-89; Zebu; chromatin immunoprecipitation; co-immunoprecipitation; hepatocellular carcinoma; histone deacetylase; immortalized non-tumorigenic hepatocyte cell line; methyl-CpG-binding protein 2; sodium valproic acid; zebularine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Up-Regulation / Epigenesis, Genetic / DNA-Binding Proteins / Bcl-2 Homologous Antagonist-Killer Protein Type of study: Prognostic_studies Language: En Journal: Biochim Biophys Acta Year: 2013 Type: Article

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