Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.

Gorlick, Richard; Kolb, E Anders; Keir, Stephen T; Maris, John M; Reynolds, C Patrick; Kang, Min H; Carol, Hernan; Lock, Richard; Billups, Catherine A; Kurmasheva, Raushan T; Houghton, Peter J; Smith, Malcolm A

Gorlick, Richard; Kolb, E Anders; Keir, Stephen T; Maris, John M; Reynolds, C Patrick; Kang, Min H; Carol, Hernan; Lock, Richard; Billups, Catherine A; Kurmasheva, Raushan T; Houghton, Peter J; Smith, Malcolm A.

Affiliation

Gorlick R; The Children's Hospital at Montefiore, Bronx, New York.

Pediatr Blood Cancer ; 61(1): 158-64, 2014 Jan.

Article in En | MEDLINE | ID: mdl-23956067

Subject(s)

Antineoplastic Agents/pharmacology; Cell Cycle Proteins/antagonists & inhibitors; Neoplasms, Experimental/drug therapy; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Pteridines/pharmacology; Animals; Antineoplastic Agents/pharmacokinetics; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Mice, SCID; Protein Kinase Inhibitors/pharmacokinetics; Pteridines/pharmacokinetics; Xenograft Model Antitumor Assays; Polo-Like Kinase 1

Key words

Plk inhibitor; developmental therapeutics; preclinical testing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pteridines / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Protein Kinase Inhibitors / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2014 Type: Article

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