CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.

Sullivan, Timothy; Miao, Zhenhua; Dairaghi, Daniel J; Krasinski, Antoni; Wang, Yu; Zhao, Bin N; Baumgart, Trageen; Ertl, Linda S; Pennell, Andrew; Seitz, Lisa; Powers, Jay; Zhao, Ruiping; Ungashe, Solomon; Wei, Zheng; Boring, Landin; Tsou, Chia-Lin; Charo, Israel; Berahovich, Robert D; Schall, Thomas J; Jaen, Juan C

Sullivan, Timothy; Miao, Zhenhua; Dairaghi, Daniel J; Krasinski, Antoni; Wang, Yu; Zhao, Bin N; Baumgart, Trageen; Ertl, Linda S; Pennell, Andrew; Seitz, Lisa; Powers, Jay; Zhao, Ruiping; Ungashe, Solomon; Wei, Zheng; Boring, Landin; Tsou, Chia-Lin; Charo, Israel; Berahovich, Robert D; Schall, Thomas J; Jaen, Juan C.

Affiliation

Sullivan T; 850 Maude Ave., Mountain View, CA 94043. rberahovich@chemocentryx.com.

Am J Physiol Renal Physiol ; 305(9): F1288-97, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-23986513

Subject(s)

Diabetic Nephropathies/drug therapy; Hyperglycemia/drug therapy; Kidney/drug effects; Receptors, CCR2/antagonists & inhibitors; Sulfonamides/pharmacology; Animals; Diabetic Nephropathies/genetics; Gene Knock-In Techniques; HEK293 Cells; Humans; Insulin Resistance; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, CCR2/genetics

Key words

albuminuria; chemokine; chemokine (C-C motif) receptor 2; hyperglycemia; macrophage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Diabetic Nephropathies / Receptors, CCR2 / Hyperglycemia / Kidney Limits: Animals / Humans / Male Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2013 Type: Article

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