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Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia.
Pérez, Mayrim L; Culver, Sarah; Owen, Jennifer L; Dunbar, Mark; Kow, Kelvin; Breen, Matthew; Milner, Rowan J.
Affiliation
  • Pérez ML; Departments of aSmall Animal Clinical Sciences bPhysiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida cDepartment of Molecular Biomedical Sciences dDepartment of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh eCancer Genetics Program, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
Anticancer Drugs ; 24(10): 1098-103, 2013 Nov.
Article in En | MEDLINE | ID: mdl-23995854
ABSTRACT
Treatment of chronic monocytic leukemia (CMoL) in dogs has traditionally consisted of hydroxyurea. The use of tyrosine kinase inhibitors has been proposed as a treatment option for dogs with CMoL but has never been reported. We report a case of CMoL in a young dog that achieved clinical remission with treatment with the tyrosine kinase inhibitor toceranib and prednisone.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Leukemia, Myeloid / Fusion Proteins, bcr-abl / Dog Diseases Limits: Animals Language: En Journal: Anticancer Drugs Journal subject: ANTINEOPLASICOS Year: 2013 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Leukemia, Myeloid / Fusion Proteins, bcr-abl / Dog Diseases Limits: Animals Language: En Journal: Anticancer Drugs Journal subject: ANTINEOPLASICOS Year: 2013 Type: Article Affiliation country: United States