Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD.

Okamura, Daryl M; Bahrami, Nadia M; Ren, Shuyu; Pasichnyk, Katie; Williams, Juliana M; Gangoiti, Jon A; Lopez-Guisa, Jesus M; Yamaguchi, Ikuyo; Barshop, Bruce A; Duffield, Jeremy S; Eddy, Allison A

Okamura, Daryl M; Bahrami, Nadia M; Ren, Shuyu; Pasichnyk, Katie; Williams, Juliana M; Gangoiti, Jon A; Lopez-Guisa, Jesus M; Yamaguchi, Ikuyo; Barshop, Bruce A; Duffield, Jeremy S; Eddy, Allison A.

Affiliation

Okamura DM; Seattle Children's Hospital Research Institute, University of Washington, Seattle, Washington;

J Am Soc Nephrol ; 25(1): 43-54, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24009239

Subject(s)

Antioxidants/therapeutic use; Cysteamine/therapeutic use; Myofibroblasts/drug effects; Renal Insufficiency, Chronic/drug therapy; Actins/metabolism; Animals; Cell Differentiation/drug effects; Cell Line; Cell Proliferation/drug effects; Disease Models, Animal; Extracellular Matrix Proteins/genetics; Fibrosis; GTP-Binding Proteins/metabolism; Macrophages/drug effects; Macrophages/pathology; Male; Mice; Mice, Inbred C57BL; Myofibroblasts/metabolism; Myofibroblasts/pathology; Oxidative Stress/drug effects; Protein Glutamine gamma Glutamyltransferase 2; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Renal Insufficiency, Chronic/metabolism; Renal Insufficiency, Chronic/pathology; Transglutaminases/metabolism; Ureteral Obstruction/drug therapy; Ureteral Obstruction/metabolism; Ureteral Obstruction/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteamine / Renal Insufficiency, Chronic / Myofibroblasts / Antioxidants Limits: Animals Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2014 Type: Article

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