Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang, Hao; Zeng, Jianing; Titsch, Craig; Voronin, Kimberly; Akinsanya, Billy; Luo, Linlin; Shen, Hongwu; Desai, Dharmesh D; Allentoff, Alban; Aubry, Anne-Françoise; Desilva, Binodh S; Arnold, Mark E

Jiang, Hao; Zeng, Jianing; Titsch, Craig; Voronin, Kimberly; Akinsanya, Billy; Luo, Linlin; Shen, Hongwu; Desai, Dharmesh D; Allentoff, Alban; Aubry, Anne-Françoise; Desilva, Binodh S; Arnold, Mark E.

Affiliation

Jiang H; Analytical and Bioanalytical Development and Discovery Chemistry Synthesis, Bristol-Myers Squibb , Princeton, New Jersey, United States.

Anal Chem ; 85(20): 9859-67, 2013 Oct 15.

Article in En | MEDLINE | ID: mdl-24024648

Subject(s)

Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/blood; Blood Chemical Analysis/methods; Macaca fascicularis/blood; Tandem Mass Spectrometry; Animals; Antibodies, Monoclonal/metabolism; Antibodies, Monoclonal/therapeutic use; Chemical Precipitation; Chromatography, Liquid; Feasibility Studies; Humans; Protein Denaturation; Time Factors; Trypsin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Chemical Analysis / Tandem Mass Spectrometry / Macaca fascicularis / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Anal Chem Year: 2013 Type: Article Affiliation country: United States

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