First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

Spring, Michele; Murphy, Jittawadee; Nielsen, Robin; Dowler, Megan; Bennett, Jason W; Zarling, Stasya; Williams, Jack; de la Vega, Patricia; Ware, Lisa; Komisar, Jack; Polhemus, Mark; Richie, Thomas L; Epstein, Judy; Tamminga, Cindy; Chuang, Ilin; Richie, Nancy; O'Neil, Michael; Heppner, D Gray; Healer, Julie; O'Neill, Matthew; Smithers, Hannah; Finney, Olivia C; Mikolajczak, Sebastian A; Wang, Ruobing; Cowman, Alan; Ockenhouse, Christian; Krzych, Urszula; Kappe, Stefan H I

Spring, Michele; Murphy, Jittawadee; Nielsen, Robin; Dowler, Megan; Bennett, Jason W; Zarling, Stasya; Williams, Jack; de la Vega, Patricia; Ware, Lisa; Komisar, Jack; Polhemus, Mark; Richie, Thomas L; Epstein, Judy; Tamminga, Cindy; Chuang, Ilin; Richie, Nancy; O'Neil, Michael; Heppner, D Gray; Healer, Julie; O'Neill, Matthew; Smithers, Hannah; Finney, Olivia C; Mikolajczak, Sebastian A; Wang, Ruobing; Cowman, Alan; Ockenhouse, Christian; Krzych, Urszula; Kappe, Stefan H I.

Affiliation

Spring M; Walter Reed Army Institute for Research, Silver Spring, MD 20910, USA.

Vaccine ; 31(43): 4975-83, 2013 Oct 09.

Article in En | MEDLINE | ID: mdl-24029408

Subject(s)

Anopheles/parasitology; Immunization/methods; Malaria Vaccines/immunology; Malaria/prevention & control; Plasmodium falciparum/immunology; Sporozoites/immunology; Adolescent; Adult; Animals; Drug-Related Side Effects and Adverse Reactions/pathology; Female; Gene Deletion; Genes, Protozoan; Healthy Volunteers; Humans; Immunization/adverse effects; Malaria Vaccines/administration & dosage; Malaria Vaccines/adverse effects; Malaria Vaccines/genetics; Male; Plasmodium falciparum/genetics; Plasmodium falciparum/pathogenicity; Vaccines, Attenuated/administration & dosage; Vaccines, Attenuated/adverse effects; Vaccines, Attenuated/genetics; Vaccines, Attenuated/immunology; Young Adult

Key words

First-in-human; Genetically attenuated parasite; Malaria; Plasmodium falciparum

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Immunization / Malaria Vaccines / Sporozoites / Malaria / Anopheles Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Animals / Female / Humans / Male Language: En Journal: Vaccine Year: 2013 Type: Article Affiliation country: United States

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