Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands.

Tang, Quan; Ni, Wen-Xiu; Leung, Chi-Fai; Man, Wai-Lun; Lau, Kenneth King-Kwan; Liang, Yimin; Lam, Yun-Wah; Wong, Wai-Yeung; Peng, Shie-Ming; Liu, Gui-Jian; Lau, Tai-Chu

Tang, Quan; Ni, Wen-Xiu; Leung, Chi-Fai; Man, Wai-Lun; Lau, Kenneth King-Kwan; Liang, Yimin; Lam, Yun-Wah; Wong, Wai-Yeung; Peng, Shie-Ming; Liu, Gui-Jian; Lau, Tai-Chu.

Affiliation

Tang Q; Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-CityU, Suzhou, Jiangsu 215123 and and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.

Chem Commun (Camb) ; 49(85): 9980-2, 2013 Nov 04.

Article in En | MEDLINE | ID: mdl-24042270

ABSTRACT

ABSTRACT

A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Coordination Complexes/chemical synthesis; Coordination Complexes/pharmacology; Ferric Compounds/chemistry; Osmium/chemistry; Antineoplastic Agents/chemistry; Apoptosis; Cell Proliferation/drug effects; Cell Survival/drug effects; Coordination Complexes/chemistry; Flow Cytometry; Hep G2 Cells; Humans; Inhibitory Concentration 50; Ligands; Molecular Structure; Osmium/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osmium / Ferric Compounds / Coordination Complexes / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2013 Type: Article Affiliation country: China

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