ASB2&#945;, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.

Razinia, Ziba; Baldassarre, Massimiliano; Cantelli, Gaia; Calderwood, David A

ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.

Razinia, Ziba; Baldassarre, Massimiliano; Cantelli, Gaia; Calderwood, David A.

Affiliation

Razinia Z; From the Departments of Cell Biology and.

J Biol Chem ; 288(44): 32093-105, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24052262

Subject(s)

Filamins/metabolism; Hematopoietic Stem Cells/metabolism; Proteasome Endopeptidase Complex/metabolism; Proteolysis; Suppressor of Cytokine Signaling Proteins/metabolism; Ubiquitin-Protein Ligases/metabolism; Animals; CHO Cells; Cricetinae; Cricetulus; Filamins/genetics; Humans; Mutation; Proteasome Endopeptidase Complex/genetics; Protein Binding; Protein Structure, Tertiary; Suppressor of Cytokine Signaling Proteins/genetics; Ubiquitin/genetics; Ubiquitin/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitination/physiology

Key words

Actin; Calponin Homology Domain; Cell Biology; Cytoskeleton; E3 Ubiquitin Ligase; Filamin; Stress Fiber

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Ubiquitin-Protein Ligases / Proteasome Endopeptidase Complex / Suppressor of Cytokine Signaling Proteins / Proteolysis / Filamins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article

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