Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD).

Cho, Soo Kyung; Pedram, Ali; Levin, Ellis R; Kwon, Young Jik

Cho, Soo Kyung; Pedram, Ali; Levin, Ellis R; Kwon, Young Jik.

Affiliation

Cho SK; Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, United States.

Biomaterials ; 34(38): 10228-37, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24055523

Subject(s)

Acids/chemistry; Breast Neoplasms/drug therapy; Nanoparticles/chemistry; Superoxide Dismutase/metabolism; Tamoxifen/chemistry; Tamoxifen/therapeutic use; Animals; Apoptosis/drug effects; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Silencing/physiology; Humans; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Superoxide Dismutase/genetics

Key words

Apoptosis; Drug-resistant tumor model; Gene therapy; RNA interference; Stimuli-responsive nanoparticles

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Tamoxifen / Acids / Breast Neoplasms / Nanoparticles Limits: Animals / Female / Humans Language: En Journal: Biomaterials Year: 2013 Type: Article Affiliation country: United States

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