Synthesis and characterization of some metal complexes of a proton transfer salt, and their inhibition studies on carbonic anhydrase isozymes and the evaluation of the results by statistical analysis.

Ilkimen, Halil; Yenikaya, Cengiz; Sari, Musa; Bülbül, Metin; Aslan, Melike; Süzen, Yasemin

Ilkimen, Halil; Yenikaya, Cengiz; Sari, Musa; Bülbül, Metin; Aslan, Melike; Süzen, Yasemin.

Affiliation

Ilkimen H; Department of Chemistry, Faculty of Arts and Sciences, Dumlupinar University , Kütahya , Turkey .

J Enzyme Inhib Med Chem ; 29(5): 695-701, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24148087

Subject(s)

Carbonic Anhydrase II/antagonists & inhibitors; Carbonic Anhydrase I/antagonists & inhibitors; Carbonic Anhydrase Inhibitors/pharmacology; Models, Statistical; Organometallic Compounds/pharmacology; Benzothiazoles/chemistry; Carbonic Anhydrase I/isolation & purification; Carbonic Anhydrase I/metabolism; Carbonic Anhydrase II/isolation & purification; Carbonic Anhydrase II/metabolism; Carbonic Anhydrase Inhibitors/chemical synthesis; Carbonic Anhydrase Inhibitors/chemistry; Dose-Response Relationship, Drug; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Metals, Heavy/chemistry; Models, Molecular; Molecular Structure; Organometallic Compounds/chemical synthesis; Organometallic Compounds/chemistry; Picolinic Acids/chemistry; Protons; Salts/chemistry; Structure-Activity Relationship

Key words

2,6-pyridinedicarboxylic acid; 2-Amino-6-methoxybenzothiazole; carbonic anhydrase; inhibition; proton transfer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Carbonic Anhydrase Inhibitors / Models, Statistical / Carbonic Anhydrase I / Carbonic Anhydrase II Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article Affiliation country: Turkey

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