Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata.

Smith, Thomas E; Hong, Weili; Zachariah, Malcolm M; Harper, Mary Kay; Matainaho, Teatulohi K; Van Wagoner, Ryan M; Ireland, Chris M; Vershinin, Michael

Smith, Thomas E; Hong, Weili; Zachariah, Malcolm M; Harper, Mary Kay; Matainaho, Teatulohi K; Van Wagoner, Ryan M; Ireland, Chris M; Vershinin, Michael.

Affiliation

Smith TE; Departments of Medicinal Chemistry and Physics and Astronomy and Center for Cell and Genome Science, University of Utah, Salt Lake City, UT 84112.

Proc Natl Acad Sci U S A ; 110(47): 18880-5, 2013 Nov 19.

Article in En | MEDLINE | ID: mdl-24191039

Subject(s)

Drug Discovery/trends; Hydroquinones/pharmacology; Kinesins/antagonists & inhibitors; Porifera/chemistry; Sulfuric Acid Esters/pharmacology; Triterpenes/pharmacology; Animals; Biophysics; Cell Membrane Permeability/physiology; Drug Discovery/methods; Humans; Hydroquinones/metabolism; Molecular Structure; Protein Binding; Spectrophotometry; Sulfuric Acid Esters/metabolism; Triterpenes/metabolism

Key words

mechanism of action; microtubule-based motors; natural products; single-molecule biophysics; terpenes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Sulfuric Acid Esters / Triterpenes / Kinesins / Drug Discovery / Hydroquinones Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Type: Article

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