Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease.

Carcelli, Mauro; Rogolino, Dominga; Bacchi, Alessia; Rispoli, Gabriele; Fisicaro, Emilia; Compari, Carlotta; Sechi, Mario; Stevaert, Annelies; Naesens, Lieve

Carcelli, Mauro; Rogolino, Dominga; Bacchi, Alessia; Rispoli, Gabriele; Fisicaro, Emilia; Compari, Carlotta; Sechi, Mario; Stevaert, Annelies; Naesens, Lieve.

Affiliation

Carcelli M; Dipartimento di Chimica,Dipartimento di Farmacia, Università di Parma , Parco Area delle Scienze 17/A, 43124 Parma, Italy.

Mol Pharm ; 11(1): 304-16, 2014 Jan 06.

Article in En | MEDLINE | ID: mdl-24206028

Subject(s)

Benzamides/chemistry; Chelating Agents/pharmacology; Coordination Complexes/pharmacology; Magnesium/metabolism; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Recombinant Proteins/chemistry; Viral Proteins/antagonists & inhibitors; Catalytic Domain; Chelating Agents/chemistry; Coordination Complexes/chemistry; Crystallography, X-Ray; Magnesium/chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; RNA-Dependent RNA Polymerase/metabolism; Recombinant Proteins/metabolism; Viral Proteins/metabolism; X-Ray Diffraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Benzamides / Recombinant Proteins / RNA-Dependent RNA Polymerase / Chelating Agents / Coordination Complexes / Magnesium Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2014 Type: Article Affiliation country: Italy

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