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Life history trade-offs in cancer evolution.
Aktipis, C Athena; Boddy, Amy M; Gatenby, Robert A; Brown, Joel S; Maley, Carlo C.
Affiliation
  • Aktipis CA; 1] Center for Evolution and Cancer and the Department of Surgery, University of California San Francisco, 2340 Sutter Street, BOX 1351, San Francisco, California 94143-1351, USA. [2] Department of Psychology, Arizona State University, PO Box 871104, Tempe, Arizona 85287-1104, USA.
Nat Rev Cancer ; 13(12): 883-92, 2013 12.
Article in En | MEDLINE | ID: mdl-24213474
ABSTRACT
Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Biological / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Rev Cancer Journal subject: NEOPLASIAS Year: 2013 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Biological / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Rev Cancer Journal subject: NEOPLASIAS Year: 2013 Type: Article Affiliation country: United States