The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan.
J Infect Dis
; 209(6): 816-27, 2014 Mar.
Article
in En
| MEDLINE
| ID: mdl-24231186
ABSTRACT
BACKGROUND:
Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan.METHODS:
Virologic and pathologic examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification and/or the detection of anti-SFTSV immunoglobulin G antibody in sera. Physicians were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS.RESULTS:
A female patient who died in 2012 received a diagnosis of SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged ≥50 years and lived in western Japan. Six cases were fatal. The ratio of males to females was 83. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis.CONCLUSIONS:
SFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phlebovirus
/
Bunyaviridae Infections
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Infect Dis
Year:
2014
Type:
Article