Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.

Quotti Tubi, Laura; Gurrieri, Carmela; Brancalion, Alessandra; Bonaldi, Laura; Bertorelle, Roberta; Manni, Sabrina; Pavan, Laura; Lessi, Federica; Zambello, Renato; Trentin, Livio; Adami, Fausto; Ruzzene, Maria; Pinna, Lorenzo A; Semenzato, Gianpietro; Piazza, Francesco

Quotti Tubi, Laura; Gurrieri, Carmela; Brancalion, Alessandra; Bonaldi, Laura; Bertorelle, Roberta; Manni, Sabrina; Pavan, Laura; Lessi, Federica; Zambello, Renato; Trentin, Livio; Adami, Fausto; Ruzzene, Maria; Pinna, Lorenzo A; Semenzato, Gianpietro; Piazza, Francesco.

J Hematol Oncol ; 6: 78, 2013 Oct 12.

Article in En | MEDLINE | ID: mdl-24283803

Subject(s)

Daunorubicin/pharmacology; Leukemia, Myeloid, Acute/therapy; Naphthyridines/pharmacology; Protein Kinase Inhibitors/pharmacology; Tumor Suppressor Protein p53/metabolism; Antibiotics, Antineoplastic/pharmacology; Apoptosis/drug effects; Apoptosis/genetics; Casein Kinase II/antagonists & inhibitors; Casein Kinase II/metabolism; Cell Growth Processes/drug effects; Cell Growth Processes/genetics; Cell Line, Tumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acute/enzymology; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/pathology; Phenazines; RNA Interference; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Daunorubicin / Tumor Suppressor Protein p53 / Protein Kinase Inhibitors / Naphthyridines Limits: Humans Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Type: Article

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