Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Tan, Ying Xim; Manz, Boryana N; Freedman, Tanya S; Zhang, Chao; Shokat, Kevan M; Weiss, Arthur

Tan, Ying Xim; Manz, Boryana N; Freedman, Tanya S; Zhang, Chao; Shokat, Kevan M; Weiss, Arthur.

Affiliation

Tan YX; Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA.
Manz BN; Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA.
Freedman TS; Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA.
Zhang C; Department of Chemistry, University of Southern California, California, USA.
Shokat KM; 1] Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
Weiss A; 1] Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [3] Department of Microbiology and Immunology, U

Nat Immunol ; 15(2): 186-94, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24317039

Subject(s)

Actins/metabolism; Cytoskeleton/metabolism; Mutant Proteins/metabolism; Receptors, Antigen, T-Cell/metabolism; Thymocytes/immunology; src-Family Kinases/metabolism; Animals; CD28 Antigens/immunology; CSK Tyrosine-Protein Kinase; Cells, Cultured; Cytochalasin D/administration & dosage; Cytoskeleton/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutant Proteins/genetics; Polymerization/drug effects; Protein Engineering; Pyrazoles/administration & dosage; Pyrimidines/administration & dosage; Receptors, Antigen, T-Cell/immunology; Signal Transduction/drug effects; Signal Transduction/genetics; Thymocytes/drug effects; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytoskeleton / Receptors, Antigen, T-Cell / Actins / Src-Family Kinases / Mutant Proteins / Thymocytes Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Type: Article Affiliation country: United States

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