YC-1 binding to the ß subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the &#945; subunit.

Purohit, Rahul; Fritz, Bradley G; The, Juliana; Issaian, Aaron; Weichsel, Andrzej; David, Cynthia L; Campbell, Eric; Hausrath, Andrew C; Rassouli-Taylor, Leida; Garcin, Elsa D; Gage, Matthew J; Montfort, William R

YC-1 binding to the ß subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.

Purohit, Rahul; Fritz, Bradley G; The, Juliana; Issaian, Aaron; Weichsel, Andrzej; David, Cynthia L; Campbell, Eric; Hausrath, Andrew C; Rassouli-Taylor, Leida; Garcin, Elsa D; Gage, Matthew J; Montfort, William R.

Affiliation

Purohit R; Department of Chemistry and Biochemistry, The University of Arizona , Tucson, Arizona 85721, United States.

Biochemistry ; 53(1): 101-14, 2014 Jan 14.

Article in En | MEDLINE | ID: mdl-24328155

Subject(s)

Guanylate Cyclase/metabolism; Indazoles/chemistry; Receptors, Cytoplasmic and Nuclear/metabolism; Allosteric Regulation/drug effects; Animals; Carbon Monoxide/chemistry; Cattle; Heme/chemistry; Manduca/enzymology; Models, Molecular; Nitric Oxide/chemistry; Protein Binding; Protein Conformation; Protein Structure, Tertiary/drug effects; Protein Subunits/metabolism; Soluble Guanylyl Cyclase; Surface Plasmon Resonance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Cytoplasmic and Nuclear / Guanylate Cyclase / Indazoles Limits: Animals Language: En Journal: Biochemistry Year: 2014 Type: Article Affiliation country: United States

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