Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis.

Krug, Norbert; Gupta, Abhya; Badorrek, Philipp; Koenen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M; Wood, Chester

Krug, Norbert; Gupta, Abhya; Badorrek, Philipp; Koenen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M; Wood, Chester.

Affiliation

Krug N; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany. Electronic address: norbert.krug@item.fraunhofer.de.
Gupta A; Boehringer Ingelheim, Biberach, Germany.
Badorrek P; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
Koenen R; Boehringer Ingelheim, Biberach, Germany.
Mueller M; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
Pivovarova A; Boehringer Ingelheim, Biberach, Germany.
Hilbert J; Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn.
Wetzel K; Boehringer Ingelheim, Biberach, Germany.
Hohlfeld JM; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
Wood C; Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn.

J Allergy Clin Immunol ; 133(2): 414-9, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24332218

Subject(s)

Anti-Allergic Agents/therapeutic use; Benzamides/therapeutic use; Pyrimidines/therapeutic use; Receptors, Immunologic/antagonists & inhibitors; Receptors, Prostaglandin/antagonists & inhibitors; Rhinitis, Allergic, Seasonal/drug therapy; Adult; Allergens/immunology; Anti-Allergic Agents/pharmacology; Benzamides/pharmacology; Cross-Over Studies; Cytokines/immunology; Double-Blind Method; Eosinophils/cytology; Female; Humans; Leukocyte Count; Male; Middle Aged; Nasal Mucosa/cytology; Nasal Mucosa/immunology; Poaceae/immunology; Pollen/immunology; Pyrimidines/pharmacology; Receptors, Immunologic/immunology; Receptors, Prostaglandin/immunology; Rhinitis, Allergic, Seasonal/immunology; Treatment Outcome

Key words

AE; AR; AUC; Adverse event; Allergic rhinitis; Area under the curve; BI 671800; CRTH2; Chemoattractant receptor homologous molecule on T(H)2 cells; ECC; ESC; Environmental challenge chamber; Eosinophil shape change; FP; FSC; Fluticasone propionate; Forward scatter; MMRM; Mixed-model repeated measure; PGD(2); Prostaglandin D(2); SAR; Seasonal allergic rhinitis; TNSS; Total nasal symptom score; environmental challenge chamber; inflammation; prostaglandin D(2); seasonal allergic rhinitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Benzamides / Receptors, Prostaglandin / Receptors, Immunologic / Rhinitis, Allergic, Seasonal / Anti-Allergic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Allergy Clin Immunol Year: 2014 Type: Article

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