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Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.
Dönmez Cakil, Yaprak; Khunweeraphong, Narakorn; Parveen, Zahida; Schmid, Diethart; Artaker, Matthias; Ecker, Gerhard F; Sitte, Harald H; Pusch, Oliver; Stockner, Thomas; Chiba, Peter.
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  • Dönmez Cakil Y; Institutes of Medical Chemistry (Y.D.C., N.K., Z.P., P.C.), Pharmacology (Y.D.C., H.H.S., T.S.), and Physiology (D.S.), Department of Medical Biochemistry, Max F. Perutz Laboratories (M.A.), and Department of Cell and Developmental Biology (O.P.), Medical University of Vienna, Vienna, Austria; Department of Biochemistry, Abdul Wali Khan University Mardan, Pakistan (Z.P.); and Emerging Field Pharmacoinformatics, Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (G.F.E.).
Mol Pharmacol ; 85(3): 420-8, 2014 Mar.
Article in En | MEDLINE | ID: mdl-24366667
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Propafenone / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Hydrogen Limits: Humans Language: En Journal: Mol Pharmacol Year: 2014 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Propafenone / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Hydrogen Limits: Humans Language: En Journal: Mol Pharmacol Year: 2014 Type: Article