Your browser doesn't support javascript.
loading
Quantitative measurement to evaluate morphological changes of the corpus callosum in patients with subcortical ischemic vascular dementia.
Wu, Xiao-Ping; Gao, Yan-Jun; Yang, Jun-Le; Xu, Min; Sun, Dong-Hai.
Affiliation
  • Wu XP; Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
  • Gao YJ; Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
  • Yang JL; Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China yangjle@163.com.
  • Xu M; Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
  • Sun DH; Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Acta Radiol ; 56(2): 214-8, 2015 Feb.
Article in En | MEDLINE | ID: mdl-24445093
ABSTRACT

BACKGROUND:

Subcortical ischemic vascular dementia (SIVD) is a subtype of dementia associated with abnormalities in the subcortical white matter regions. Recent imaging techniques can be used to detect such abnormalities in vivo.

PURPOSE:

To examine morphological changes of the corpus callosum in patients with SIVD by using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). MATERIAL AND

METHODS:

MRI was performed to explore changes of cerebral white matter, especially corpus callosum. Brain matter diffusivity was examined with DTI by measuring the fractional anisotropy (FA). Results of 30 patients diagnosed with SIVD and 30 healthy subjects were analyzed and compared.

RESULTS:

The thicknesses of the genu, the anterior third, middle, and posterior third of the body, and the splenium of the corpus callosum were smaller in SIVD patients compared to healthy controls (0.54 ± 0.08 vs. 0.68 ± 0.09 cm, P = 0.0011; 0.27 ± 0.06 vs. 0.38 ± 0.07 cm, P = 0.002; 0.28 ± 0.05 vs. 0.38 ± 0.08 cm, P = 0.009; 0.18 ± 0.04 vs. 0.26 ± 0.06 cm, P = 0.013; 0.54 ± 0.07 vs. 0.72 ± 0.09 cm, P = 0.003, respectively). The FA values of the genu and splenium of the corpus callosum in patients with SIVD were decreased compared to healthy controls (0.664 ± 0.042 vs. 0.778 ± 0.041, P < 0.001; 0.691 ± 0.038 vs. 0.786 ± 0.039, P = 0.001, respectively).

CONCLUSION:

Patients with SIVD exhibit corpus callosum atrophy and morphological changes, and these characteristics may be useful for diagnosis.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pattern Recognition, Automated / Image Interpretation, Computer-Assisted / Dementia, Vascular / Brain Ischemia / Corpus Callosum / Diffusion Tensor Imaging / White Matter Type of study: Diagnostic_studies / Evaluation_studies Limits: Aged / Female / Humans / Male Language: En Journal: Acta Radiol Year: 2015 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pattern Recognition, Automated / Image Interpretation, Computer-Assisted / Dementia, Vascular / Brain Ischemia / Corpus Callosum / Diffusion Tensor Imaging / White Matter Type of study: Diagnostic_studies / Evaluation_studies Limits: Aged / Female / Humans / Male Language: En Journal: Acta Radiol Year: 2015 Type: Article