[On general physical aspects of a problem of in vivo effective detection and recognition of malignant cells].
Biofizika
; 58(4): 645-51, 2013.
Article
in Ru
| MEDLINE
| ID: mdl-24455884
ABSTRACT
A fundamentally new recognition method of bio-objects (in particular malignant cells) that escape the immune system supervision control is suggested. Recognition of such bio-objects should be carried out by the unified complex consisting of several molecular groups (for example, antibodies) bound to each other, each group identifies on a surface of this bio-object its target binding site. The choice of such targets is determined by a specific surface-antigen expression profiling. Thus the efficiency of recognition appears to be many times higher, than that in a situation when these molecular groups do not form a uniform complex and operate separately. The possibilities of destruction of such recognized cells are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Immunological
/
Nanoparticles
/
Antibodies
/
Antigens, Neoplasm
/
Neoplastic Cells, Circulating
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Ru
Journal:
Biofizika
Year:
2013
Type:
Article