Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction.

Shi, Lei; Zhang, Qipeng; Xu, Binqiang; Jiang, Xiaohong; Dai, Yutian; Zhang, Chen-Yu; Zen, Ke

Shi, Lei; Zhang, Qipeng; Xu, Binqiang; Jiang, Xiaohong; Dai, Yutian; Zhang, Chen-Yu; Zen, Ke.

Affiliation

Shi L; From the Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China and.

J Biol Chem ; 289(12): 8432-41, 2014 Mar 21.

Article in En | MEDLINE | ID: mdl-24519936

Subject(s)

Acrosome Reaction; Infertility/enzymology; Infertility/etiology; Obesity/complications; Obesity/enzymology; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Spermatozoa/physiology; Animals; Female; Fertilization in Vitro; Humans; Infertility/metabolism; Male; Mice; Mice, Inbred C57BL; Obesity/metabolism; SNARE Proteins/metabolism; Spermatozoa/enzymology; Spermatozoa/metabolism

Key words

Obesity; Obesity, Subfertility/Infertility, PTP1B, Dephosphorylation, N-Ethylmaleimide-sensitive Factor; Phosphatase; Phosphorylation; SNARE Proteins; Sperm

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Acrosome Reaction / Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Infertility / Obesity Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2014 Type: Article

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