Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.

Maciag, Anna E; Holland, Ryan J; Kim, Youseung; Kumari, Vandana; Luthers, Christina E; Sehareen, Waheed S; Biswas, Debanjan; Morris, Nicole L; Ji, Xinhua; Anderson, Lucy M; Saavedra, Joseph E; Keefer, Larry K

Maciag, Anna E; Holland, Ryan J; Kim, Youseung; Kumari, Vandana; Luthers, Christina E; Sehareen, Waheed S; Biswas, Debanjan; Morris, Nicole L; Ji, Xinhua; Anderson, Lucy M; Saavedra, Joseph E; Keefer, Larry K.

Affiliation

Maciag AE; Chemical Biology Laboratory, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.

J Med Chem ; 57(6): 2292-302, 2014 Mar 27.

Article in En | MEDLINE | ID: mdl-24521039

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Glutathione S-Transferase pi/metabolism; Neoplasms/enzymology; Nitric Oxide/metabolism; Poly(ADP-ribose) Polymerase Inhibitors; Apoptosis/drug effects; Boronic Acids/pharmacology; Bortezomib; Cell Line, Tumor; Cell Proliferation/drug effects; Comet Assay; DNA Damage; Drug Design; Drug Synergism; Enzyme Inhibitors/pharmacology; Humans; Isoenzymes/drug effects; Models, Molecular; Neoplasms/drug therapy; Poly (ADP-Ribose) Polymerase-1; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Pyrazines/pharmacology; Structure-Activity Relationship; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glutathione S-Transferase pi / Poly(ADP-ribose) Polymerase Inhibitors / Neoplasms / Antineoplastic Agents / Nitric Oxide Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Type: Article Affiliation country: United States

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