Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis.
Infection
; 42(4): 775-8, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-24531907
ABSTRACT
Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridazines
/
Rifampin
/
Tuberculosis
/
HIV Infections
/
Anti-HIV Agents
/
Antitubercular Agents
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Infection
Year:
2014
Type:
Article
Affiliation country:
Italy