Engineering Xenopus embryos for phenotypic drug discovery screening.

Schmitt, Stefan M; Gull, Mazhar; Brändli, André W

Schmitt, Stefan M; Gull, Mazhar; Brändli, André W.

Affiliation

Schmitt SM; Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
Gull M; Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
Brändli AW; Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address: abrandli@med.lmu.de.

Adv Drug Deliv Rev ; 69-70: 225-46, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24576445

Subject(s)

Drug Discovery/methods; Genetic Engineering/methods; Phenotype; Xenopus/embryology; Animals; Drug Discovery/trends; Drug Evaluation, Preclinical/methods; Drug Evaluation, Preclinical/trends; Genetic Engineering/trends; Humans; Life Cycle Stages/physiology

Key words

CRISPR/Cas; Genome editing; Human disease models; Morpholinos; TALENs; Transgenesis; Xenopus laevis; Xenopus tropicalis; Zebrafish; Zinc-finger nucleases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Xenopus / Genetic Engineering / Drug Discovery Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2014 Type: Article Affiliation country: Germany

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