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A new ursane-type triterpene, cymosic acid from Rosa cymosa.
Wu, Xiao-Peng; Zhang, Xiao-Po; Ma, Guo-Xu; Han, Mo; Xu, Mu-Die; Wu, Hai-Feng; Huang, Xiao-Yan; Huang, Zhen; Yang, Jun-Shan; Yuan, Jing-Quan; Xu, Xu-Dong; Zhong, Xiao-Ming.
Affiliation
  • Wu XP; a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou 310053 , China.
J Asian Nat Prod Res ; 16(4): 422-5, 2014.
Article in En | MEDLINE | ID: mdl-24597721
A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3ß,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its ¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Drugs, Chinese Herbal / Rosa Limits: Animals Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2014 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Drugs, Chinese Herbal / Rosa Limits: Animals Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2014 Type: Article Affiliation country: China